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KMID : 1123920030170010230
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Korean Journal of Oriental Physiology and Pathology
2003 Volume.17 No. 1 p.230 ~ p.240
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Effect of Hwao-tang on Superoxide Generation and Neutrophil Functions
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Park Soo-Young
Choi Dall-Yeong
Kim Cherl-Ho
Park Won-Hwan
Kim Han-Geu
Lee Soo-Kyung
Ahan Jong-Chan
Chung Tae-Wook
Moon Jin-Young
Park Sun-Dong
Kim June-Ki
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Abstract
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We investigated that Hwao-tang had various effects on stimulus-induced superoxide generation in human neutrophils. Hwao-tang significantly inhibited N-formyl-methionyl-leucyl-phenylalanine-induced superoxide generation in a concentration-dependent manner, but not that induced by arachidonic acid. Also, Hwao-tang significantly reduced mouse paw oedema induced by carrageenan. The results suggest that protein tyrosine kinase participates in fMLP-mediated superoxide generation by Hwao-tang-treated human neutrophils. Also, the results indicate that Hwao-tang exerts anti-inflammatory effects related to the inhibition of neutrophil functions and of NO and prostaglandin E2 production, which could be due to a decreased expression of iNOS and COX-2.
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KEYWORD
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Hwao-tang(huayutang, 化瘀湯), neutrophils, superoxide generation, iNOS, COX-2
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